"Serotonin, depression, and aggression: The problem of brain energy.
Extremely serious mistakes about the nature of the solar system didn't matter too much until interplanetary travel became a possibility. Extremely serious mistakes about brain "transmitters" and "receptors" didn't matter too much until the drug industry got involved.
"Three years before Prozac received approval by the US Food and Drug Administration in late 1987, the German BGA, that country's FDA equivalent, had such serious reservations about Prozac's safety that it refused to approve the antidepressant based on Lilly's studies showing that previously nonsuicidal patients who took the drug had a fivefold higher rate of suicides and suicide attempts than those on older antidepressants, and a threefold higher rate than those taking placebos."
"Using figures on Prozac both from Lilly and independent research, however, Dr. David Healy, an expert on the brain's serotonin system and director of the North Wales Department of Psychological Medicine at the University of Wales, estimated that "probably 50,000 people have committed suicide on Prozac since its launch, over and above the number who would have done so if left untreated."
The Boston Globe, 2000.
Anyone who has been reading the mass media and watching television in recent decades is familiar with the use of tryptophan as an antidepressant. Tryptophan is easily converted to serotonin and melatonin in the body. The most popular kind of antidepressant, the “serotonin reuptake inhibitor”, is said to act by increasing the action of serotonin in the brain. Many people have read articles in popular science magazines explaining that a deficiency of serotonin can cause depression, suicide, and aggression. Estrogen is often said to achieve its “wonderful” effects by increasing the effects of serotonin."
Serotonin, depression, and aggression: The problem of brain energy
"Beginning with the industrial production of glutamic acid (sold as MSG, monosodium glutamate), the public has been systematically misinformed about the effects of amino acids in the diet. The FDA has been industry's powerful ally in misleading the public. Despite research that clearly showed that adults assimilate whole proteins more effectively than free amino acids, much of the public has been led to believe that “predigested” hydrolized protein and manufactured free amino acids are more easily assimilated than real proteins, and that they are not toxic. Even if free amino acids could be produced industrially without introducing toxins and allergens, they wouldn't be appropriate for nutritional use."
Tryptophan, serotonin, and aging.
Serotonin, Endotoxin and Stress.
Misconceptions about Melatonin and Serotonin.